SPPL2A Back

signal peptide peptidase like 2A

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NCBI Description of SPPL2A

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPPL2A is highly significantly mutated in
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SPPL2A is significantly mutated in
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SPPL2A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SPPL2A