SPO11 Back

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

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NCBI Description of SPO11
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

Community Annotation of SPO11 Add / Edit SPO11: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPO11 is highly significantly mutated in
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SPO11 is significantly mutated in
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SPO11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SPO11