SPN Back

sialophorin (leukosialin, CD43)

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NCBI Description of SPN
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response.

Community Annotation of SPN Add / Edit SPN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPN is highly significantly mutated in
(none)
SPN is significantly mutated in
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SPN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SPN