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NCBI Description of SPINT2 |
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. |
Community Annotation of SPINT2 Add / Edit SPINT2: Annotations
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Figure notes
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Data details