SPINT1 Back

serine peptidase inhibitor, Kunitz type 1

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NCBI Description of SPINT1
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.

Community Annotation of SPINT1 Add / Edit SPINT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPINT1 is highly significantly mutated in
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SPINT1 is significantly mutated in
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SPINT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SPINT1