serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

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NCBI Description of SPINK2

This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants.

Community Annotation of SPINK2 Add / Edit SPINK2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SPINK2 is highly significantly mutated in
SPINK2 is significantly mutated in
SPINK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SPINK2