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SPEG complex locus

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NCBI Description of SPEG
This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Studies in mouse have determined that a lack of this protein affected myocardial development. Multiple alternatively spliced transcript variants have been reported for this gene, but the full-length nature of only two variants that encode different protein isoforms has been defined.

Community Annotation of SPEG Add / Edit SPEG: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SPEG is highly significantly mutated in
(none)
SPEG is significantly mutated in
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SPEG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SPEG