secreted protein, acidic, cysteine-rich (osteonectin)

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NCBI Description of SPARC

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.

Community Annotation of SPARC Add / Edit SPARC: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SPARC is highly significantly mutated in
SPARC is significantly mutated in
SPARC is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SPARC