SP2 Back

Sp2 transcription factor

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SP2

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.

Community Annotation of SP2 Add / Edit SP2: Annotations

Added by Vera Kaiser

0

Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SP2 is highly significantly mutated in
(none)
SP2 is significantly mutated in
(none)
SP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SP2