SP100 Back

SP100 nuclear antigen

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SP100

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein.

Community Annotation of SP100 Add / Edit SP100: Annotations

No community annotations yet for SP100.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SP100 is highly significantly mutated in
SP100 is significantly mutated in
SP100 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SP100