SP1 Back

Sp1 transcription factor

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SP1
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SP1 Add / Edit SP1: Annotations

No community annotations yet for SP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SP1 is highly significantly mutated in
(none)
SP1 is significantly mutated in
(none)
SP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SP1