SOX10 Back

SRY (sex determining region Y)-box 10

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SOX10

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Community Annotation of SOX10 Add / Edit SOX10: Annotations

No community annotations yet for SOX10.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOX10 is highly significantly mutated in
(none)
SOX10 is significantly mutated in
(none)
SOX10 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SOX10