SOSTDC1 Back

sclerostin domain containing 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SOSTDC1
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Community Annotation of SOSTDC1 Add / Edit SOSTDC1: Annotations

No community annotations yet for SOSTDC1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOSTDC1 is highly significantly mutated in
(none)
SOSTDC1 is significantly mutated in
(none)
SOSTDC1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SOSTDC1