SOD2 Back

superoxide dismutase 2, mitochondrial

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SOD2

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Community Annotation of SOD2 Add / Edit SOD2: Annotations

No community annotations yet for SOD2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOD2 is highly significantly mutated in
(none)
SOD2 is significantly mutated in
(none)
SOD2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SOD2