SOD1 Back

superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))

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NCBI Description of SOD1
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOD1 is highly significantly mutated in
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SOD1 is significantly mutated in
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SOD1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SOD1