SOCS4 Back

suppressor of cytokine signaling 4

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NCBI Description of SOCS4

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Community Annotation of SOCS4 Add / Edit SOCS4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SOCS4 is highly significantly mutated in
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SOCS4 is significantly mutated in
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SOCS4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SOCS4