SNX27 Back

sorting nexin family member 27

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NCBI Description of SNX27
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.

Community Annotation of SNX27 Add / Edit SNX27: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SNX27 is highly significantly mutated in
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SNX27 is significantly mutated in
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SNX27 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SNX27