SNCB Back

synuclein, beta

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SNCB
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.

Community Annotation of SNCB Add / Edit SNCB: Annotations

No community annotations yet for SNCB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SNCB is highly significantly mutated in
(none)
SNCB is significantly mutated in
(none)
SNCB is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SNCB