SMURF1 Back

SMAD specific E3 ubiquitin protein ligase 1

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NCBI Description of SMURF1
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMURF1 is highly significantly mutated in
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SMURF1 is significantly mutated in
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SMURF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMURF1