SMPD4 Back

sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)

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NCBI Description of SMPD4
Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM, Mar 2008].

Community Annotation of SMPD4 Add / Edit SMPD4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMPD4 is highly significantly mutated in
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SMPD4 is significantly mutated in
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SMPD4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMPD4