SMPD2 Back

sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

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NCBI Description of SMPD2

This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.

Community Annotation of SMPD2 Add / Edit SMPD2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SMPD2 is highly significantly mutated in
SMPD2 is significantly mutated in
SMPD2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SMPD2