SMG6 Back

Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)

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NCBI Description of SMG6
This gene encodes a protein which is part of the telomerase ribonucleoprotein complex and binds single-stranded DNA found at the telomeres, but the product of this gene also participates in the nonsense-mediated mRNA decay (NMD) pathway. The encoded protein contains two binding sites for components of the exon junction complex (EJC); interaction between the encoded protein and the EJC is necessary for NMD activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SMG6 Add / Edit SMG6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMG6 is highly significantly mutated in
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SMG6 is significantly mutated in
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SMG6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMG6