SMG1 Back

smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SMG1
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.

Community Annotation of SMG1 Add / Edit SMG1: Annotations

No community annotations yet for SMG1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMG1 is highly significantly mutated in
(none)
SMG1 is significantly mutated in
(none)
SMG1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMG1