sperm mitochondria-associated cysteine-rich protein

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NCBI Description of SMCP

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.

Community Annotation of SMCP Add / Edit SMCP: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SMCP is highly significantly mutated in
SMCP is significantly mutated in
SMCP is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SMCP