SMARCE1 Back

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

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NCBI Description of SMARCE1
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.

Community Annotation of SMARCE1 Add / Edit SMARCE1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMARCE1 is highly significantly mutated in
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SMARCE1 is significantly mutated in
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SMARCE1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMARCE1