SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

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NCBI Description of SMARCD3

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SMARCD3 is highly significantly mutated in
SMARCD3 is significantly mutated in
SMARCD3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SMARCD3