SMARCA5 Back

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

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NCBI Description of SMARCA5
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of SMARCA5 Add / Edit SMARCA5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMARCA5 is highly significantly mutated in
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SMARCA5 is significantly mutated in
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SMARCA5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMARCA5