SMARCA2 Back

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

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NCBI Description of SMARCA2
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMARCA2 is highly significantly mutated in
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SMARCA2 is significantly mutated in
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SMARCA2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMARCA2