SMAD6 Back

SMAD family member 6

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NCBI Description of SMAD6
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SMAD6 Add / Edit SMAD6: Annotations

No community annotations yet for SMAD6.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMAD6 is highly significantly mutated in
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SMAD6 is significantly mutated in
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SMAD6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMAD6