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SMAD family member 5

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NCBI Description of SMAD5

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Community Annotation of SMAD5 Add / Edit SMAD5: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SMAD5 is highly significantly mutated in
SMAD5 is significantly mutated in
SMAD5 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SMAD5