SMAD3 Back

SMAD family member 3

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NCBI Description of SMAD3
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Community Annotation of SMAD3 Add / Edit SMAD3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SMAD3 is highly significantly mutated in
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SMAD3 is significantly mutated in
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SMAD3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SMAD3