SLCO1C1 Back

solute carrier organic anion transporter family, member 1C1

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NCBI Description of SLCO1C1
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLCO1C1 is highly significantly mutated in
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SLCO1C1 is significantly mutated in
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SLCO1C1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLCO1C1