SLCO1B3 Back

solute carrier organic anion transporter family, member 1B3

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NCBI Description of SLCO1B3
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of SLCO1B3 Add / Edit SLCO1B3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLCO1B3 is highly significantly mutated in
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SLCO1B3 is significantly mutated in
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SLCO1B3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLCO1B3