SLC9A3R2 Back

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

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NCBI Description of SLC9A3R2

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of SLC9A3R2 Add / Edit SLC9A3R2: Annotations

No community annotations yet for SLC9A3R2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC9A3R2 is highly significantly mutated in
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SLC9A3R2 is significantly mutated in
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SLC9A3R2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SLC9A3R2