SLC7A7 Back

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

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NCBI Description of SLC7A7

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants.

Community Annotation of SLC7A7 Add / Edit SLC7A7: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC7A7 is highly significantly mutated in
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SLC7A7 is significantly mutated in
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SLC7A7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SLC7A7