SLC6A4 Back

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

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NCBI Description of SLC6A4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. There is an upstream in-frame AUG at nt 451-453 with a weak Kozak signal. This was not annotated as the translation start because it has a weak Kozak signal, while the downstream AUG at nt 577-579 has a strong Kozak signal, and is not conserved in-frame in other vertebrates except chimp.

Community Annotation of SLC6A4 Add / Edit SLC6A4: Annotations

No community annotations yet for SLC6A4.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


SLC6A4 is highly significantly mutated in
SLC6A4 is significantly mutated in
SLC6A4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for SLC6A4