SLC6A3 Back

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SLC6A3
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence. Sequence Note: Variation in the number of 40 bp repeats in the 3' UTR of this gene has been reported with a normal range of 3 to 11 repeats. The Reference Sequence contains 10 copies of these repeats.

Community Annotation of SLC6A3 Add / Edit SLC6A3: Annotations

No community annotations yet for SLC6A3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC6A3 is highly significantly mutated in
(none)
SLC6A3 is significantly mutated in
(none)
SLC6A3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC6A3