SLC6A2 Back

solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

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NCBI Description of SLC6A2
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Community Annotation of SLC6A2 Add / Edit SLC6A2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC6A2 is highly significantly mutated in
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SLC6A2 is significantly mutated in
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SLC6A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC6A2