SLC4A4 Back

solute carrier family 4, sodium bicarbonate cotransporter, member 4

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NCBI Description of SLC4A4

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SLC4A4 Add / Edit SLC4A4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC4A4 is highly significantly mutated in
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SLC4A4 is significantly mutated in
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SLC4A4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SLC4A4