SLC4A11 Back

solute carrier family 4, sodium borate transporter, member 11

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NCBI Description of SLC4A11
This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described.

Community Annotation of SLC4A11 Add / Edit SLC4A11: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC4A11 is highly significantly mutated in
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SLC4A11 is significantly mutated in
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SLC4A11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC4A11