SLC4A10 Back

solute carrier family 4, sodium bicarbonate transporter-like, member 10

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NCBI Description of SLC4A10
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of SLC4A10 Add / Edit SLC4A10: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC4A10 is highly significantly mutated in
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SLC4A10 is significantly mutated in
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SLC4A10 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC4A10