SLC45A2 Back

solute carrier family 45, member 2

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NCBI Description of SLC45A2
This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SLC45A2 Add / Edit SLC45A2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC45A2 is highly significantly mutated in
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SLC45A2 is significantly mutated in
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SLC45A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC45A2