SLC30A8 Back

solute carrier family 30 (zinc transporter), member 8

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NCBI Description of SLC30A8
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Community Annotation of SLC30A8 Add / Edit SLC30A8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC30A8 is highly significantly mutated in
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SLC30A8 is significantly mutated in
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SLC30A8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC30A8