SLC25A27 Back

solute carrier family 25, member 27

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of SLC25A27
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.

Community Annotation of SLC25A27 Add / Edit SLC25A27: Annotations

No community annotations yet for SLC25A27.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC25A27 is highly significantly mutated in
(none)
SLC25A27 is significantly mutated in
(none)
SLC25A27 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC25A27