SLC22A4 Back

solute carrier family 22 (organic cation/ergothioneine transporter), member 4

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NCBI Description of SLC22A4

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.

Community Annotation of SLC22A4 Add / Edit SLC22A4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC22A4 is highly significantly mutated in
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SLC22A4 is significantly mutated in
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SLC22A4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for SLC22A4