SLC22A2 Back

solute carrier family 22 (organic cation transporter), member 2

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NCBI Description of SLC22A2
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of SLC22A2 Add / Edit SLC22A2: Annotations

No community annotations yet for SLC22A2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC22A2 is highly significantly mutated in
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SLC22A2 is significantly mutated in
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SLC22A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC22A2