SLC22A12 Back

solute carrier family 22 (organic anion/urate transporter), member 12

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NCBI Description of SLC22A12
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.

Community Annotation of SLC22A12 Add / Edit SLC22A12: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC22A12 is highly significantly mutated in
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SLC22A12 is significantly mutated in
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SLC22A12 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC22A12