SLC1A2 Back

solute carrier family 1 (glial high affinity glutamate transporter), member 2

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NCBI Description of SLC1A2
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

Community Annotation of SLC1A2 Add / Edit SLC1A2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC1A2 is highly significantly mutated in
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SLC1A2 is significantly mutated in
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SLC1A2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC1A2