SLC1A1 Back

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

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NCBI Description of SLC1A1
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC1A1 is highly significantly mutated in
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SLC1A1 is significantly mutated in
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SLC1A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC1A1