SLC18A1 Back

solute carrier family 18 (vesicular monoamine), member 1

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NCBI Description of SLC18A1
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

SLC18A1 is highly significantly mutated in
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SLC18A1 is significantly mutated in
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SLC18A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for SLC18A1